Open your Prada purse and remove all of the contents. Unzip any inner pockets and remove small items such as loose change. Turn the open, empty purse upside down and shake the purse over a garbage can to remove loose dust and debris.
Clean your Prada leather purse with a good-quality cleaner made specifically for leather. Dip a soft cotton cloth into the leather cleaner, then wipe the leather cleaner onto the purse in circular motions.
Dampen a separate cotton cloth, and use it to remove the leather cleaner. Use a separate, clean cloth to buff the leather, and to remove any last traces of leather cleaner.
Condition your Prada leather purse with a good-quality leather conditioner. The conditioner will restore moisture to the leather, preventing the leather from drying and keeping the purse soft and smooth. Use the leather conditioner according to the guidelines on the container. Allow the leather to dry completely before using or storing your bag.
Store your Prada leather purse in the dust bag that came with the purse. Alternatively, store the purse in a clean, cotton pillowcase. Wrap any chrome or metal parts in acid-free tissue paper. Loosen any attachments such as straps or buckles if you intend to store your Prada bag for an extended period to prevent the attachments from leaving indentations or creases in the leather.
Always handle your Prada leather bag with clean hands; the leather can absorb oil and dirt from your skin.
Keep your makeup in a separate pouch inside your bag to protect your Prada from accidental spills. Place ink pens in a protective pouch or container inside your bag.